Some people with Waldenstrom’s macroglobulinaemia may have higher levels of an antibody that is sensitive to cold temperatures. These antibodies are called cryoglobulins. When your body temperature drops below normal, cryoglobulins will clump together and block blood flow, usually in your hands, feet, ears and nose.
Pain in your hands or feet when you’re cold
Blue tinge to your hands and feet when you’re cold
Skin lesions that are purple or red-brown
Skin ulcers
Gangrene
Swollen ankles and legs
Joint pain
It’s important to raise these symptoms with your doctor, as it could be a sign that your Waldenstrom’s macroglobulinaemia is progressing and you might need to start treatment. Your doctor will take blood tests to diagnose the condition, and to check for any other underlying causes for it.
In most cases, your doctor will take a conservative approach to treating your cryoglobulinaemia. This means that they will advise you take steps to keep your body temperature up to avoid the symptoms, instead of immediately going on treatment. For example, you could wear more layers and avoid cold food and drink.
If your symptoms are severe or getting worse, or your blood tests suggest that your WM is progressing, your doctor may decide that it’s time to consider treatment for your WM.
