The UK charity for Waldenstrom’s macroglobulinaemia – a rare type of blood cancer
Support Line: 0300 373 8500

A Study of Oral LOXO-305 in Patients With Previously Treated CLL/​SLL or NHL

Understanding the best dosage for a BTK inhibitor called Pirtobrutinib
Main Aims

This study is looking at how a new type of BTK inhibitor, Pirtobrutinib, works in patients with certain types of lymphoma, including WM.
It is split into different phases, giving researchers insight into what the best dosage is, and how it might work with other treatments. Pirtobrutinib is different to other BTK inhibitors as it reacts differently with the cells they target.

This study is on-going but currently closed to recruitment.

Recruitment Criteria

• Confirmed diagnosis of WM;

• You were intolerant to 2 or more standard care regimens or received a BTK inhibitor as first line treatment

Recruitment status: Not Recruiting
Sponsor: Loxo Oncology
Expected to end: 01/01/2028
Phases: