The UK charity for Waldenstrom’s macroglobulinaemia – a rare type of blood cancer
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Study of Iopofosine I 131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) and Pivotal Expansion in Waldenstrom Macroglobulinemia (CLOVER-WaM)

Measuring the efficacy of a drug called Iopofosine I131 in patients with WM
Main Aims

This study has two parts. The first measures the efficacy of Iopofosine I 131 in patients with some B-cell cancers. The second part focusses in particular on WM patients who have received at least two lines of treatment previously.
Iopofosine I 131 is a type of targeted treatment known as a radiotherapeutic. It delivers radiation direct to certain cancer cells by targeting them, and has been shown to be effective in other types of cancer.

This study is on-going but currently closed to recruitment.

Recruitment Criteria

• Confirmed diagnosis of WM (people diagnosed with LPL may be eligible)

• Part A of the study – Previously treated with standard therapy

• Part B of the study – Received two prior lines of treatment

Recruitment status: Not Recruiting
Sponsor: Cellectar Biosciences Inc
Expected to end: 22/12/2026
Phases:
Regions: